Trendlines report: 10 companies to watch

10 companies to watch icon

Editor’s note: This information appeared in NextInsight.

Introducing our “10 companies to watch” report. Our growing portfolio of 44 companies range from “just started” through those selling products and growing internationally.

The companies in this report are characterized by having made significant technological progress; five have already begun sales in global markets.

ApiFix • Arcuro BioFishencyEdenShieldEscalaFidmi MedicalGordian Surgical • Leviticus CardioMemTechVensica Medical

We intend to update this report on a quarterly basis.

Note: References appear at the bottom of the page.


Minimally invasive scoliosis treatment device

ApiFix aims to disrupt the scoliosis device market with its minimally invasive, non-fusion spinal implant system for the correction of Adolescent Idiopathic Scoliosis (AIS). Worldwide there are approximately 126,000 scoliosis procedures per year, of which 40,000 are AIS, representing a US$2.4 billion implant market.[1]

Status update

  • 4 distribution agreements executed (UK, France, Turkey, Mexico), sales have begun
  • 3 granted U.S. patents (1 in national phase)
  • CE Mark certification received allowing European sales

Arcuro Medical

All-suture, “all-inside” meniscus repair system
Arcuro Medical is developing an all-suture meniscus repair system that preserves knee functionality and is secure, safe, reliable, and effective.  According to MedDevice Tracker, the global meniscus repair market is currently valued at US$ 300 million. Arcuro[2] believes that with its easy-to-use system, more surgeons will repair the meniscus instead of removing it and, as a result, Arcuro expects to convert a portion of the 1.5 million meniscus removal procedures performed annually to repair procedures.

Status update

  • IP: national phase (China, Israel, USA, Europe)
  • Successful cadaver studies
  • EN/ISO 13485:2012 certification completed


All-in-one water treatment system for land-based aquaculture
BioFishency’s cost-effective, plug-and-play water treatment system enhances water quality, making it possible to double production in ponds and to reduce water use by up to 95% in tanks. Aquaculture is the fastest growing sector in animal protein production with a market value of US$156 billion in 2015 and expected to reach US$209 billion in 2021.[3] By 2023, 62% of food fish will come from aquaculture.[4]

Status update

  • BioFishency units already operating in China, Indonesia, the Congo, Bangladesh, India, Singapore, Israel, and others
  • Distribution agreements for Bangladesh, India, Taiwan and China; cooperation with several strategic partners
  • IP: patent in national phase


Natural plant-based crop protection solutions
EdenShield’s natural nontoxic crop protection products leverage characteristics of plants that originate in Israel’s semi-desert region to mask plant odor and significantly lower insect attraction, eliminating the need for harsh pesticides. The global market for biopesticides was valued at US$3.7 billion in 2015 and has been projected to grow to US$7.7 billion in 2021, reflecting a 14.1% compound annual growth rate of over the period.[5] These markets are looking for cost-effective, environmentally friendly solutions that are synergistic with their existing products.

Status update

  • Ongoing sales in Israel, Italy, Greece, and Spain
  • Distributor agreements including the EU, US, and Mexico
  • Expanding farming operations to meet growing sales
  • IP: U.S., Australia patent granted; patent published in Europe, Canada, India, Mexico and China; patent filed in Israel and Kenya

Escala Medical

Nonsurgical, incision-free approach to treat pelvic organ prolapse
Escala Medical developed the first repair device for the treatment of pelvic organ prolapse (POP) based on a nonsurgical, incision-free, mesh-free repair approach. More than 34 million women are affected annually worldwide; with a lifetime prevalence of 50% among women who have given birth. It is forecast that by 2050, the incidence of women with POP will increase by 46%.[6]

Status update

  • Successful cadaver studies
  • IP: 1 national phase (U.S., EU, China, Brazil); 1 provisional patent pending in the U.S.
  • Signed term sheet for investment from top-20 medtech multinational

Fidmi Medical

Novel feeding device for improved nutrition delivery
Fidmi Medical has developed a uniquely designed, low-profile, enteral feeding device that offers a secure, reliable, discreet solution immediately post-surgery. With almost four million feeding tubes placed annually representing sales of US$540 million, Transparency Market Research estimates that the global market will exceed US$600 million by 2018.[7]

Status update

  • Successful initial placements of tubes in patients
  • Submitted FDA 510(k)
  • IP: three patents pending (two in national phase)
  • Signed term sheet for investment from top-20 medtech multinational

Gordian Surgical

Novel integrated port closure system
Gordian Surgical has developed the TroClose1200, an integrated port closure system, acting as a trocar through which surgical instruments enter the abdomen, and a device to close internal incisions made during surgery.

Status update

  • Company signed 5 distribution agreements (UK, France, Turkey, Mexico, Panama) and began sales
  • IP: 3 granted U.S. patents (1 in national phase)
  • FDA regulatory clearance and CE Mark certification
  • Performed over 120 surgeries

Leviticus Cardio

Wireless energy system for LVADs
Leviticus Cardio is developing a wireless solution to provide the energy needs of left ventricular assist device (LVAD) implants, eliminating the need for a driveline, a potential entry point for infection. According to Grand View Research, the global LVAD market was valued at US$763 million in 2014 and is set to grow to US$ 1.98 billion by 2022,[8] driven by increased prevalence of cardiovascular disease, advances in technology and favorable reimbursement, among other factors.

Status update

  • ISO 13485
  • Successful chronic animal trials and integration with LVADs
  • IP: 8 issued patents; 4 pending in the United States


Game-changing membranes for water treatment
MemTech’s ultrafiltration membranes have more than 2 times higher flux capacity (at similar quality) compared to leading commercial membranes, and are sold for wastewater treatment, pretreatment, drinking water treatment, and nanofiltration. The global membrane wastewater treatment technology market is estimated to reach US$12 billion by 2020 with annual growth of 10.2%.[9]

Status update

  • Increasing sales of membrane products; initial sales of integrated filtration system; expanding partner relationships and product offerings
  • Growing list of industry partners and of customers include Mekorot (Israel’s national water company) and SEB Alliance


Ultrasound-assisted drug-delivery for overactive bladder
Vensica Medical is developing VensiCare to treat overactive bladder (OAB) with ultrasound delivering Botox® into the bladder wall painlessly, without needles; the procedure can be performed in the doctor’s office or clinic, without anesthesia. OAB is the most common bladder disorder. There are an estimated 33 million OAB patients in the United States alone.[10]

Status update

  • Successful preclinical trials
  • Signed term sheet for new investment by undisclosed strategic investor


[1] U.S. National Center for Health Statistics; OECD Health Data 2015; Statistique annuelle des établissements de santé and CNAMTS (Evolution des actes techniques en secteur liberal); Statistisches Bundesamt; Conjunto Mínimo Básico de Datos – Hospitalización and Ambulatorio; UK Hospital Episode Statistics databases for Admitted Patient Care and Outpatients; Life Science Intelligence Surgical Procedure Volume database.

[2] MedDevice Tracker, March 2017, Arthroscopy and Sports Medicine Devices Market.

[3] “Aquaculture Market (Carp, Molluscs, Crustaceans, Salmon, Trout and Other Fish) by Culture (Marine Water, Fresh Water and Brackish Water): Global Industry Perspective, Comprehensive Analysis, Size, Share, Growth, Segment, Trends and Forecast, 2015 – 2021.” September 2016. Zion Market Research.

[4] “FISH TO 2030 Prospects for Fisheries and Aquaculture.” December 2013. The World Bank.

[5] “Global Markets for Biopesticides,” January 2017. BCC Research.

[6] Int Urogynecol J (2013) 24: 1783-1790; Epidemiology and outcome assessment of pelvic organ prolapse; Matthew D. Barber, Christopher Maher. Obstet Gynecol. January 2014; 123(1): 141-148; Prevalance and Trends of Symptomatic Pelvic Floor Disorders in U.S. Women.

[7] “Enteral Feeding Devices Market: Global Industry Size, Market Share, Trends, Analysis, 2012-2018.” Transparency Market Research.

[8] “Congestive Heart Failure (CHF) Treatment Devices Market Analysis by Product (Ventricular Assist Devices, Counter Pulsation Devices, Implantable Cardioverter Defibrillators, Pacemakers, Cardiac Resynchronization Therapy) And Segment Forecasts to 2024.” October 2016. Grand View Research.

[9] Frost Perspectives: Augmentation of Membrane Filtration Technology Market. June 2016. Frost & Sullivan.

[10] The Burden of Overactive Bladder on US Public Health; Curr Bladder Dysfunct Rep, 2016 March, W. Stuart Reynolds , Jay Fowke, Roger Dmochowski. The Total Economic Burden of Overactive Bladder in the United States: A Disease-Specific Approach;

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