Zygofix is developing ZLock, a miniature implant that achieves spinal joint fusion and spinal stability without using screws.

The Zygofix Opportunity

The market seeks an improved minimally invasive solution for spinal fusion that offers minimum trauma and maximum efficacy.

The Zygofix Novel Implant

Zygofix is developing the ZLock, a miniature implant that achieves spinal fusion and spinal stability without using screws. Its novel implant is inserted between the spine’s facet joints to create fusion and spinal stability. By inserting Zlock in the facet joints, the surgeon utilizes the natural construction of the vertebrae to provide spinal stability, and thereby eliminates the need to insert pedicle screws.

Due to its unique design and placement, ZLock provides numerous advantages:

  • Lack of screws reduces procedure complexity
  • Percutaneous, minimally invasive approach can be performed in an outpatient setting
  • 2 incisions (one incision on each side of the spine) lead to a less traumatic procedure
  • Efficient bone growth and fusion (implant has porous texture)
  • Flexible design fits most any anatomy

ZLock can be used as a stand-alone fusion device or as a stabilization adjunct to other fusion procedures.

The Team

  • Ofer Levy, CEO: 10+ years’ experience in medical device industry, R&D, and product development; MBA Tel Aviv University; B.Sc. mechanical engineer, Ben-Gurion University of the Negev
  • Uri Arnin, Co-founder and CTO: Serial medical entrepreneur; 30 years’ experience in medical device industry; 26 issued patents and 39+ pending (all in spine); former CTO Impliant (world’s first facet replacement device), CTO Spine 21 (world’s first remote-controlled spinal implant), founder and CTO ApiFix
  • Prof Yizhar Floman, Co-founder & Medical Director: Chairman and Director of the Israel Spine Center, Assuta Hospital, Tel Aviv; former Chief of Spine Surgery, Hadassah Hebrew University Medical Center, Jerusalem, President of the Israel Orthopedic Association, member of numerous organizations, including Scoliosis Research Society, International Society for the Study of the Lumbar Spine, Spine Society of Europe, and the North American Spine Society


Stage: Technology development
Founded: December 2016
Investor: The Trendlines Group
IP: Submitted PCT
Award: One of the 10 best new spine technologies for 2017 (Orthopedics This Week)

The Background and Market

Disorders of the lower back (lumbar spine) such as degenerative disc disease, spondylolisthesis (slipped vertebra), and spinal stenosis (narrowing of the spinal canal) may result in severe back and leg pain. Depending on the severity, minimally invasive lumbar spinal fusion surgery may be recommended to limit movement and reduce pain.

This procedure involves (1) creating bone fusion by placing an implant in the disc space located between the two vertebrae and (2) providing additional spinal stability by inserting pedicle screws and a short rod to improve clinical outcomes.

Unfortunately, there are limitations to the current procedure, including making six incisions to insert four pedicle screws and two rods. Furthermore, 5% of all screws are misplaced and require surgical revision.

Worldwide: There are 700,000 spinal cage procedures performed annually. Zygofix estimates its global market at $772 million based on an estimated 46% of the (relevant) market.


The ZLock implant (circled) developed by Zygofix achieves facet joint fusion without screws. 


Ofer Levy, CEO

Zygofix logo

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